home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9409d.zip
/
M9490517.TXT
< prev
next >
Wrap
Text File
|
1994-09-24
|
2KB
|
37 lines
Document 0517
DOCN M9490517
TI [Foscarnet for cytomegalovirus retinitis in a patient with acquired
immunodeficiency syndrome]
DT 9411
AU Nagata Y; Fujino Y; Ono A; Mochizuki M; Mouri H; Oka S; Kimura S;
Shimada K; Department of Ophthalmology, University of Tokyo School of;
Medicine, Japan.
SO Nippon Ganka Gakkai Zasshi. 1994 Jul;98(7):710-5. Unique Identifier :
AIDSLINE MED/94346332
AB A 41-year-old man with acquired immunodeficiency syndrome (AIDS)
developed cytomegalovirus (CMV) retinitis. Intravenous administration of
ganciclovir arrested progression of the retinitis, but it was
discontinued due to side effects of severe anemia, neutropenia, and
thrombocytopenia. Reactivation of CMV retinitis occurred two weeks after
stopping ganciclovir, and then forscarnet was given intravenously. The
response was prompt with resolution of the retinitis. There was no
progression of retinitis during the treatment. The patient experienced
renal dysfunction as a side effect of foscarnet, but it was reversible.
As with ganciclovir, foscarnet appeared to be an effective drug for CMV
retinitis associated with AIDS. Both drugs have severe adverse events:
foscarnet causes renal dysfunction and ganciclovir causes
myelosuppression, that necessitated discontinuation of the therapy. We
suggest that alternating ganciclovir and foscarnet administration,
switching to other treatment on the basis of the clinical response and
side effects of the drugs, is an efficacious regimen for the treatment
of CMV retinitis associated with AIDS.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult AIDS-Related
Opportunistic Infections/*DRUG THERAPY Case Report Cytomegalovirus
Retinitis/COMPLICATIONS/*DRUG THERAPY English Abstract
Foscarnet/*THERAPEUTIC USE Ganciclovir/THERAPEUTIC USE Human Male
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).